Vitamin D, Crohn's Disease and Colitis
20 November 2015 | Editor
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Vitamin D and Crohn's disease
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A 2008 study measured the incidence of vitamin D deficiency in 130 Inflammatory Bowel Disease patients (94 with Crohn’s disease and 36 with colitis) aged 8-22, and found a convincing correlation.
Two years later a further study showed that this was no coincidence: vitamin D deficiency actually seems to play a causative role, at least with Crohn’s disease. The researchers started with the premise that the inflammation in the intestines is caused by the immune system’s inability to respond correctly to intestinal bacteria. They showed that vitamin D is directly involved in the expression of the NOD2 gene, which signals the presence of invading microbes in the intestines, and its failure to be expressed has previously been linked to Crohn’s disease. The team writes: “Our observation that 1,25D signaling is a direct inducer of NOD2 expression argues strongly that vitamin D insufficiency/deficiency does play a causative role in the prevalence of Crohn’s disease.”
We have a number of articles about different aspects of Vitamin D and the vital roll it plays. Click of any link below to look at that subject or, below the links, click to bring up a printable PDF document covering all of the subjects by the excellent Nutrigold company, which also incorporates references.