Coenzyme Q10 Reduces Vascular problems in Diabetes

15 May 2015  |  Editor

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Example ImageCoQ10 can help vascular injury in diabetes

Diabetics have double the risk of vascular injury, or damage to the blood vessels, which can cause problems throughout the body ranging from ulcers in the foot and lower leg, and decreased sensation in peripheral nerve endings, to heart failure, kidney failure and stroke.

It has generally been thought that the blood vessels are damaged due to the increased levels of glucose in their blood leading to more glycoproteins being made, which makes the basement membrane thicker and weaker. However, more recent research is challenging this theory, as 40% diabetics who control their blood sugar still develop neuropathy1, and the non-diabetic children of many type 2 diabetics also develop neuropathy and blood vessel stiffness.2

A group of researchers at Singapore’s Alexandra Hospital decided to have a look at coenzyme Q10’s involvement, and found that their ubiquinol levels were severely low – in fact 75% lower than the non-diabetics tested.3 Ubiquinol is the “reduced” form of coenzyme Q10 that is ready to act as an antioxidant: as it performs its role as an antioxidant, it becomes ubiquinone. The researchers therefore concluded that the diabetics were using up their ubiquinol in response to high levels of oxidative stress, and converting it to ubiquinone.

Both forms are available as a supplement, but the more active form of ubiquinol may be more useful for diabetics and their offspring to help them regain integrity in their blood vessels.

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