How the cannabinoids work in the human body is extremely complex, and we are only beginning to understand the details of this mechanism. Just think about this: half a century ago we did not know about the existence of a whole separate endocannabinoid system, and just a decade ago, hardly anyone wondered about the “entourage effect”. Equally complex is how does the CBD – the key beneficial component of hemp -work. This interaction is extremely complex and includes various ways of CBD binding to receptors, as well as its indirect effects (primarily its effect on anandamide). The effects of cannabidiol on the serotonin system – a matter that is only recently being studied, although it can bring about a breakthrough in the antipsychotic and anti-depressant potential of hemp. Today, we are closing our mini-cycle discussing the impact of CBD on other receptors, sometimes very exotic ones. As we shall see, the effect the hemp’s most important cannabinoid exerts on the human body is extremely complex and includes its surprising interactions with the vanilloid, adenosine, dopamine and even opioid systems, among others.
First, a small reminder. The fact that we can analyze the action of CBD on many levels and on many different receptors of many different systems stems from the pleiotropy and promiscuity of this cannabinoid. Pleiotropy refers to the fact that a substance has more than one specific effect, while its promiscuity – yup, that’s an actual scientific term – hints at the fact that it has more than one pharmacological target, that is – it is likely to bind at more than one type of receptors. This second property – the promiscuity of cannabinoids – spurs molecules to look for more than one molecular partner and thanks to that one can consider effects of CBD also outside its “dedicated” endocannabinoid system.
Among many remarkable beneficial properties of cannabis more and more we learn about the CBD potential in the fight against addictions. Fortunately, gone are the days when dealing with addictions to cannabis might have seemed a paradox. Now we know more about hemp’s main medicinal ingredient potential – cannabidiol, and further studies continue to bring some very promising results. It seems that the CBD can help in the treatment of alcoholism, as well as bring aid in treating those addicted to tobacco or drugs. As usually in the case of this remarkable plant, its effect is multifarious and multifaceted, but primarily they are related to the very mechanism of addiction, especially to the vicious circle of craving and relapse. Let’s see how CBD can help to treat alcoholism – and other addictions.
At the end of March Friedbert Weisse of the California Institute of La Jolla and his team published their research results. American scientists studied relapse in alcohol and cocaine addiction models on rats (rodents had been effectively addicted to these substances by having a constant on-demand access to them). The results were very promising and consistent with the findings of several other studies – carried out on both human and animal models. Administration of the CBD (in form of a topical gel!) effectively weakened the anxiety and stress associated with exposure to the relapse cues (such as stressful situations, or the presence of the substance itself). What is important – the effect prevailed even many months after the experimental therapy.
Of course, this does not mean that the addiction was “cured.” But to appreciate the importance of the latest discovery (as well as findings of other studies discussed here) first we need to understand the mechanism of addiction.
Among dozens of potential and proven pro-health properties of CBD hemp oils, bringing relief in skin problems is still one of the less discussed. Meanwhile, more and more we learn about the potential of cannabinoids in alleviating the symptoms of acne. Acne is of course a disease hormonal and as such it should be treated by a specialist, but it seems that hemp products from the CBD may be a temporary remedy. Although the CBD hemp oil is usually used sublingually, thanks to their good penetration through the skin cannabinoids may work here applied topically. Today we introduce you to the potential importance of cannabidiol (and other cannabinoids) in the fight against acne – and ordinary pimples.
Acne and cannabinoids
To understand how cannabinoids could potentially help in the fight against acne, you must first understand how those horrible pimples are formed in the first place. Virtually the entire surface of the human body (except for the inner side of the feet and hands) is covered with sebaceous glands. A certain type of these glands is also found in the hair follicles. Sebaceous glands, as the name suggests, secrete sebum – oily, lipid substance consisting primarily of glycerides. Sebum production depends on many factors, such as hygiene, skin type, age, climate, diet, lifestyle – and most of all on the hormonal balance. The latter factor is particularly important – if we talk about acne as a disease (“hormonal acne” is a more serious thing than a transient problem with a few pimples), then there is no “curing” it until our hormones are fixed. In such case any other activities (including those described in this article) are only a way to deal with the symptoms and not with the cause of the disease. But let’s get back to the mechanism of the formation of acne. When the production of sebum is too high, the gland clogs up and effectively creating those notorious pimples.
Recently, endocannabinoid system’s receptors were discovered in sebaceous glands and hair follicles. As we recall, this system’s main feature is to regulate performance of countless body parts, and its work depends on the endocannabinoids produced by the body, mainly on the anandamide. The discovery that the mechanism of production of sebum is controlled by the endocannabinoid system has opened the possibility to study the potential use of the plant cannabinoids (phytocannabinoids) in the treatment of symptoms of acne.
CBD For Children
Along with the increase in the general knowledge of hemp and cannabis, so grows the support for their medicinal and general pro-health applications. And it’s not just about the buzz around the so-called “medical marijuana”, also to the hemp products rich in CBD, such as CBD hemp oil, are gaining more acceptance. And with the increase of this acceptance, questions arise about the safety of giving the CBD hemp oils to children. There are hundreds of anecdotal and scientifical reports on the efficacy of cannabis products in treating youngest patients/consumers, yet no wonder that many parents are still extremely cautious – after all, they have been told for years that cannabis is one of the worst threats to their children! So today we will briefly discuss the most important use of hemp essential CBD in children, dosage and risks. At the same time let us remind you that although the CBD hemp oils currently available in Poland CBD have the status of dietary supplements (and only such application will be discussed here), any worries and concerns associated with their use – not only in children – should be discussed your doctor.
Is an interesting paradox that despite the enormous controversy that has always surrounded the administration of cannabis products to kids, they were precisely children who experienced cases of spectacular recoveries and they were what children diseases (such as children’s epilepsy, or Dravete syndrome) which were the first serious illnesses, legally and on large-scale treated with cannabis-derived medicines. Cases like the one Charlotte Figi undoubtedly attracted media attention. The efficacy of cannabinoids in the treatment of drug-resistant epilepsies in children is already confirmed scientifically.
Here, however, we will be dealing with more prosaic cases of drawing from benefits of hemp – the use of CBD-rich dietary supplements in children. Let’s look at the most common (yet inevitably mainly anecdotal) cases of CBD hemp oil use.