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Nutri D3 Drops 1000 IU
Liquid Vitamin D Formula
D3 Drops 1000™ is a powerful new vitamin D formula
from Nutri Ltd. A single strawberry flavoured drop will provide 1000iu of the
preferred form of vitamin D, cholecalciferol. Current research suggests that
vitamin D may be able to support immune function, healthy inflammatory pathways,
prostate health, bone density, and hair, skin and nail health.
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Name:
Nutri D3 Drops 1000IU - 28ml
Code:
nu3400
Price: Ł Add to Basket |
D3 Drops 1000 is a liquid vitamin D formula that allows convenient, flexible
dosing. Each single drop provides 1000 IU of the preferred form of vitamin D,
cholecalciferol.
Recommended Use:
1-5 drops daily. Can be mixed into water or juice as desired.
D3 Drops 1000™ may help to support:
Ingredients:
Each one drop contains:
Vitamin D3 (cholecalciferol) 1000 IU (25 mcg)
Other ingredients:
Deionised water, Glycerin, Polyethelene glycol, Natural flavour, Vitamin E,
Potassium sorbate, Lactic Acid
Features:
Vitamin D has a multitude of biological functions in the body which may help to
support cellular health, immune function and healthy inflammatory processes, as
well as supporting bone health.
Vitamin D3 (cholecalciferol) is the preferred form of supplemental vitamin D as
this is the form produced by the skin in response to sun exposure.
D3 Drops 1000 is a pleasant tasting liquid formula, with a natural strawberry
flavour.
Caution: None known if directions are followed.
Nutri D3 drops are suitable for Vegetarians
Vitamin D: The Epidemic Deficiency of a Super-Nutrient Which
Has So Many Health Benefits
BY RACHEL BARTHOLOMEW BA (Hons) Dip (Lic.) ION
How much vitamin D do you need?
Recent medical research indicates that human daily
requirements of vitamin D may be up ten times more than what
is currently recommended. A recent study carried out by
researchers from the University of California and published in
the Journal of Nutrition has found that the current
recommended intakes of vitamin D for people with darker skins
should be increased to between 2100 and 3100 International
Units (IU) per day, a huge increase from the current daily
recommendation of 200 IU. The researchers also found that
people of European ancestry with a high sun exposure need
1300 IU vitamin D daily during winter months1.
If you consider that the skin will naturally produce
approximately 10,000 IU vitamin D in response to 20 – 30
minutes summer sun exposure, current daily recommendations
of 200 IU are further brought into question.
In his recent article on vitamin
D entitled, “What have we
learned about vitamin D dosing?” the respected scientist,
Joseph Pizzorno recommends that an average daily maintenance
dose of 5000 IU vitamin D is more realistic to promote optimal
vitamin D levels2.
When considering supplementation
with vitamin D,
recommended intakes will vary between individuals depending
on the following factors affecting vitamin D status:
• Skin pigmentation - people with darker skins are
more likely to suffer from vitamin D deficiency
• Use of sunscreen - topical application with sunscreen
(SPF 8) reduces cutaneous production of vitamin D3
by 97.5%
• Latitude and angle of sun due to seasonal changes –
vitamin D deficiency is more common in colder
climates and in the winter months
• Amount of bare skin sunlight exposure on a daily
basis – longer periods of bare skin exposure to sunlight
will promote increased vitamin D production
• Ageing has a dramatic influence on the production of
vitamin D – older adults are more likely to suffer from
vitamin D deficiency
Vitamin D & Musculoskeletal
Health
Vitamin D is absolutely crucial for musculoskeletal health; it is
essential for bone growth and development in children and
continues to promote optimal skeletal health in adults. A study
published recently in the British Medical Journal involving
almost 70,000 people from Europe and the US found that a
vitamin-mineral combination of vitamin D & calcium may help
to reduce fracture risk3. Vitamin D is essential for the bone
growth and remodelling process carried out by osteoblasts and
osteoclasts. It also regulates calcium and phosphorus levels in
the blood by promoting their absorption in the intestines.
Severe deficits in vitamin D may lead to muscle weakness,
defective bone mineralisation and rickets, the debilitating
childhood disease associated with bone softening and
deformity. Studies have also found that optimal levels of
vitamin D throughout childhood may help to reduce the risk of
osteoporosis later in life.
Vitamin D & Brain Health
More recently, the benefits of vitamin D for brain health have
been under the spotlight, particularly with regard to conditions
such as Alzheimer’s Disease4 and Autism. Although research is
still in its infancy in this area, scientists are starting to draw
significant parallels between vitamin D deficiency and the
autism spectrum of disorders. Researchers have urged that
vitamin D deficiency should be examined in more detail as a
candidate risk factor for neurodevelopmental disorders.
In a recent critical review, published in the Federation of
American Societies for Experimental Biology (FASEB) Journal,
scientists highlighted the role of the vitamin in maintaining
brain health, noting the wide distribution of vitamin D receptors
throughout the brain. According to the review, the vitamin has
been reported to affect proteins in the brain, known to be
directly involved in learning and memory, motor control, and
possibly even maternal and social behaviour5.
Vitamin D, Mood & Depression
Research published in 2008 in the Archives of General
Psychiatry has shown that increased intake of vitamin D can
improve mood and protect against depression. In the study,
researchers found low levels of vitamin D and higher blood
levels of parathyroid hormone to be associated with higher rates
of depression among 1282 people aged between 65 and 95.
Lead author Witte Hoogendijk from the Vrije Universiteit
Amsterdam commented,
"this large population-based study shows, for the first time, an
association of depression status and depression severity with
decreased serum 25(OH)D levels and increased serum PTH
levels in older subjects”6.
Sunlight – ‘A Relative Cancer
Immunity’?
The link between vitamin D intake and protection from cancer
dates from the 1940s when Frank Apperley demonstrated a link
between latitude and deaths from cancer, and suggested that
sunlight gave "a relative cancer immunity."
Chronic vitamin D deficiency is now strongly associated with
an increased risk of dying from colon, prostate, breast and
ovarian cancer7. Vitamin D’s anti-cancer power is thought to be
due to its ability to block the growth of new blood vessels that
allow tumours to grow, a process called angiogenesis.
More recently, a study from Germany has demonstrated strong
links between vitamin D intake and protection from cancer.
Data was collected from 3,299 patients taking part in the
Ludwigshafen Risk and Cardiovascular Health study. Results
showed that death from fatal cancer was significantly reduced
by 55% amongst people with higher vitamin D levels8.
Harvard researchers have shown that higher vitamin D levels
are associated with better survival rates in colorectal cancer
patients. The researchers looked at data from 1017 participants
in the Nurses’ Health Study and Health Professionals Follow-
Up Study previously diagnosed with colorectal cancer. Results
showed that those people with the highest average levels of the
non-active storage form of the vitamin, 25-hydroxyvitamin D
(25-(OH)D), had a cancer specific mortality half that of people
with the lowest average levels. Another exciting find from the
Harvard study was that high levels of vitamin D were associated
with an overall mortality level which was 40% lower than
people with the lowest average levels9.
Vitamin D & Cardiovascular
Health
There is now an abundance of research to support the link
between vitamin D deficiency and poor cardiovascular health10.
A study published recently in the Journal of the American
Geriatrics Society has found that older people who are vitamin
D deficient may be at an increased risk of mortality from heart
disease than those with adequate levels.
Lead author of the study, Adit Ginde, from the University of
Colorado Denver School of Medicine commented, “It’s likely
that more than one third of older adults now have vitamin D
levels associated with higher risks of death and few have levels
associated with optimum survival. Given the ageing
population, and the simplicity of increasing a person’s level of
vitamin D, a small improvement in death rates could have a
substantial impact on public health.”
The researchers also concluded that current dosage
recommendations of vitamin D are inadequate to support
optimal general health and reduced mortality11.
A separate study published in 2008 in the Archives of Internal
Medicine found that men who are deficient in vitamin D have
more than double the normal risk of suffering a heart attack12.
Data from epidemiological studies suggest that conditions that
decrease vitamin D synthesis in the skin, such as having dark
skin and living in temperate latitudes, are associated with
increased prevalence of hypertension13.
Vitamin D & Inflammation
Researchers in Belgium have recently shown that vitamin D
lowers C-Reactive Protein (CRP), a measure of inflammation in
the body, in critically ill patients14. Even small amounts of
vitamin D, about 500IU per day, lowered inflammation by more
than 25% in a small group of critically ill patients. Another
marker of inflammation (IL-6) was reduced even more. The
researchers also found that critically ill patients were
profoundly deficient in vitamin D.
In another study, researchers found that vitamin D deficiency is
associated with increased inflammation in otherwise healthy
people15. Increased inflammation in the body can increase the
risk of chronic inflammatory conditions, including coronary
heart disease (CHD) and diabetes. Further, the researchers
found that inflammation was lowered by vitamin D. Since
vitamin D is associated with reduced risk of numerous illnesses
with inflammatory components, such as hypertension, heart
disease, diabetes and autoimmune illness, the findings were
considered extremely important.
Widespread Vitamin D
Deficiency in Children & Adolescents
Vitamin D levels in children and adolescence have a direct
influence on a child’s future bone density and risk for other
diseases. Insufficient levels of vitamin D can also stunt growth
and foster weight gain during puberty according to a recent
study published in the Journal of Clinical Endocrinology &
Metabolism16. Studies have found that there is widespread
vitamin D deficiency in children and adolescents. Researchers
have speculated that vitamin D levels in youngsters may be low
because of lack of exposure to sunlight and use of sunscreens
due to skin cancer concerns. The increasing popularity of
computer games, television and DVDs also means that children
now generally spend less time playing outdoors.
Results of a study published in the Archives of Paediatrics &
Adolescent Medicine found that 40% of the children studied
(aged between 2 and 8 years old) had insufficient levels of
vitamin D, with 12% considered deficient and 28% at risk
of deficiency. Researchers also found that a third of the
children tested were already showing signs of skeletal
problems17. These results mirror an earlier study by the
same research team, which found that 42% of teenagers
were vitamin D deficient18.
Another study published in the American Journal of Clinical
Nutrition measured blood levels of vitamin D in 382 healthy
children between the ages of 6 and 21. Of the subjects, 55% of
the children had inadequate vitamin D blood levels and 68%
overall had low blood levels of the vitamin during the winter
months.
Babette Zernel PhD., a nutritional anthropologist and primary
investigator of this study commented, “vitamin D deficiency
remains an under-recognised problem overall, and is not
well studied in children”.
Additional research published in this journal suggests that the
current children’s RDA for vitamin D (200IUs) does not
sufficiently support the bone growth and musculo-skeletal
health of children and adolescents. Children and adolescents
are more likely to be vitamin D deficient due to rapid skeletal
growth, and are far less likely to reach vitamin D levels that
doctors would consider to be toxic. Some researchers have
suggested that vitamin D at doses equivalent to 2,000 IUs a day
is not only safe for adolescents but is actually necessary for
achieving desirable vitamin D levels.
Vitamin D & Autoimmunity
The body of research behind vitamin D means that it is now not
viewed simply as a vitamin with a role in promoting bone
health, but as a complex hormone that helps to regulate the
immune system function.
Long-term vitamin D deficiency has been linked to immune
disorders such as Multiple Sclerosis (MS), Rheumatoid Arthritis
(RA), Type 1 Diabetes (IDDM), Inflammatory Bowel Disease
(IBD) and some cancers19,20&21. Researchers have found
experimentally, that vitamin D deficiency results in the
increased incidence of autoimmune disease. Data is now also
emerging that suggests there may be a role for vitamin D in the
development of self-tolerance22.
Autoimmune responses are mediated by immune cells called T
cells. 1,25 (OH)2 D has been found to modulate T cell
responses, such that the autoimmune responses are diminished.
Epidemiological studies have found that the prevalence of
IDDM, MS and RA increase as latitude increases, suggesting
that lower exposure to UVB radiation and associated decreases
in vitamin D synthesis may play a role in the pathology of these
diseases.
What’s the best way of
increasing vitamin D intake?
Since vitamin D isn’t naturally present in many foods, it isn’t
possible to achieve optimal vitamin D intake from food sources
alone. The risk of skin cancer from excessive sunlight or sunbed
exposure opens an important debate over spending more
time in the sun to increase vitamin D levels. Therefore, most
experts now agree that supplementation is currently the safest
and most effective method of achieving optimal vitamin D
status. Supplements should contain vitamin D in the form of
vitamin D3 (Cholecalciferol), since this is the form naturally
produced by the skin upon exposure to sunlight and data has
shown this is the most efficient form at increasing serum
vitamin D levels23.
Bio-available liquid vitamin D supplementation
Liquid vitamin D supplements are most commonly
recommended because they are more easily digested, absorbed
and utilised by the body and can be particularly useful for
patients who have compromised digestive function. Liquid
vitamin D supplementation is versatile and suitable for the
whole family to take, and is especially suitable for children who
may find it difficult to swallow capsules or tablets.
References
1. Hall, Kimlin, Aronov et al. Journal of Nutrition Published online ahead of
print, doi: 10.3945/jn.109.115253 ‘Vitamin D intake needed to maintain
target serum 25-hydroxyvitamin D concentrations in participants with low
sun exposure and dark skin pigmentation is substantially higher than current
recommendations’
2. Pizzorno J. Integrative Medicine Vol. 9 No. 1 Feb/Mar 2010 ‘What have we
learned about vitamin D dosing?’
3. Abrahamsen British Medical Journal 2010; 340: b5463 Published online, doi:
10.1136/bmj.b5463 ‘Patient level pooled analysis of 68 500 patients from
seven major vitamin D fracture trials in US and Europe’
4. Llewellyn DJ, Langa K, Lang I. Serum 25-Hydroxyvitamin D Concentration
and Cognitive Impairment J Geriatr Psychiatry Neurol. 2008 Dec 10
5. McCann, Ames Federation of American Societies for Experimental Biology
(FASEB) Journal Volume 22, Pages 982-1001 "Review Article: Is there
convincing biological or behavioural evidence linking vitamin D deficiency
to brain dysfunction"
6. Hoogendijk, Lips, Dik et al. Archives of General Psychiatry
May 2008, Volume 65, Number 5 "Depression Is Associated With Decreased
25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older
Adults"
7. Li, Kong et al. 1, 25-dihydroxyvitamin D3 is a negative endocrine regulator
of the rennin-angiotensin system. J Clin Invest 2002, 110: 229-238
8. Pilz, Dobnig et al. Cancer Epidemiology, Biomarkers & Prevention
2008, Volume 17, Number 5, Pages 1228-1233, doi:1055-9965.EPI-08-0002
"Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in
Patients Referred to Coronary Angiography”
9. Wolpin, Meyerhardt et al. British Journal of Cancer Volume 101, Pages 916-
923, doi: 10.1038/sj.bjc.6605262 Prospective study of predictors of vitamin
D status and survival in patients with colorectal cancer
10. Zitterman, Frisch et al. American Journal of Clinical Nutrition May
2009, Volume 89, Pages 1321-1327. Vitamin D supplementation enhances
the beneficial effects of weight loss on cardiovascular risk markers
11. Ginde, Scragg et al. Journal of the American Geriatrics Society
September 2009, Volume 57, Issue 9, Pages: 1595-1603 Prospective Study
of Serum 25-Hydroxyvitamin D level, cardiovascular disease mortality, and
all-cause mortality in older U.S. adults
12. Archives of Internal Medicine June 9, 2008; 168 (11); 1174-1180
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