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The Algae Extract
With Myriad Health Benefits
For centuries people throughout Asia have consumed Ecklonia Cava Extract (ECE),
a specie of edible brown algae. Harvested from the coastal waters of Japan,
Korea and China, all studies indicate ECE offers outstanding health benefits.
FIBROMYALGIA
Fibromyalgia patients underwent a 2 month, double-blinded study on ECE and
results
showed improved sleep patterns, energy levels, 30% pain reduction and 40%
overall improvement. (The placebo patients had no improvement.)
VASCULAR INFLAMMATION
Researchers into coronary artery disease found ECE inhibits oxidation of LDL
('bad') cholesterol better than green tea. It helps remove plaque and reduces
vascular inflammation, which also affects the body's inflammatory response.
ATHEROSCLEROSIS
Serranol
A clinical trial confirmed ECE's capacity to regenerate the cells critical to
the blood vessels' inner lining and recover their plasticity after 6 weeks'
treatment. It demonstrates ECE's ability to reverse atherosclerosis.
CARDIOVASCULAR
Ecklonia Cava Extract's many health benefits provide additional
cardiovascular protection for obese patients, who are more prone to
cardiovascular and coronary heart disease.
MEMORY
Memory can be improved by ECE, increasing the blood flow rate in the carotid
artery. Another study revealed ECE compounds prevented sleepiness in bus drivers
and students due to extra blood flow and oxygen delivery to the brain.
ANTIOXIDANT
Where the aged brain may suffer reduced blood flow and inflammatory
reactions, the ECE compound Fucoidan has protective effect. Its antioxidants and
anti-inflammatory activity disable neuro-toxic free-radical activity.
CHOLESTEROL
Researchers gave 39 people with high cholesterol, average age 55, low dose
ECE compounds for 6 weeks. This resulted in moderate drops in cholesterol LDL
and Triglycerides and rise in 'good' HDL.
JOINT SUPPORT
A favourable combination of ECE's natural anti-inflammatory and
tissue-protective properties appears to help improve arthritis and neuralgia.
Cartilage cells treated with ECE had up to 80% reduction in degeneration.
BLOOD PRESSURE
Another ECE compound is a bradykinin equivalent, the hormone produced by the
body, maintaining blood vessels dilated, encouraging healthy blood flow and
blood pressure.
BRAIN FUNCTION
Researchers have found ECE inhibits beta-amyloidal deposit in the brain, the
accumulating substance of Alzheimer's disease. Rats learned maze challenges
faster, showing short-term memory improvement.
RELAXATION
An EEG study on healthy middle age volunteers found that ECE compounds can
increase alpha-waves, an indicator of relaxation.
ALLERGIES
ECE plays a beneficial role in significantly relieving allergic reactions
without the side- effects of anti-histamine drugs.
COPD
Findings suggest ECE compounds may prevent or reverse progressive chronic
lung disease such as asthma and Chronic Obstructive Pulmonary Disease.
WEIGHT LOSS
A beverage containing 200mg ECE was given daily to 141 young adults. After 2
weeks, their weight dropped 2.5 pounds, muscle mass increased by 2.5 pounds, and
body fat dropped 4 pounds, or 7.48%.
DIABETES
A mouse study showed ECE reversed fat deposits in liver and pancreas cells
and inhibited inflammation. Excessive fat deposit and inflammation result in
insulin insensitivity and type 2 diabetes.
PENILE DYSFUNCTION
ECE compounds produce the chemical nitric oxide (NO) that keeps the arterial
walls relaxed and dilated. Scientists studied 31 men with erectile dysfunction
for over 6 months and found ECE scores higher than with Viagra.
Recommended ECE product:
Serranol, professional strength
Serranol combines two anti-inflammatory ingredients, Serrapeptase and
Curcumin, with the strong calming effects of Ecklonia Cava and the immune
boosting power of Vitqamin D3.
Ecklonia Cava References, Published Studies
· “Compound For Improving Hypertension Containing Inhibitors Of Angiotensin
Converting Enzyme Activity Extracted From Marin Plants And Articles Comprising
Thereof”, Korean Patent Application 10-2004-24347 (Livechem, Inc).
· “Composition For Prevention And Improvement Of Dementia And Promotion Of
Memory, And Healthy Assistance Foodstuffs Containing The Composition” Korean
Patent Application# 10-2003-88177 (Assigned To Haengwoo Lee).
· Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, Kim J.
Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the
brown alga Ecklonia cava. Biol Pharm Bull. 2004 Apr;27(4):544-7.
· Aikawa, T., S. Shimura, H. Sasaki, M. Ebina, And T. Takishima. 1992. Marked
Goblet Cell Hyperplasia With Mucus Accumulation In The Airways Of Patients Who
Died Of Severe Acute Asthma Attack. Chest 101:916-921.
· Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of
an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol. 2006
Jul;44(7):1065-74. Epub 2006 Mar 3.
· Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, Jonas U.
Plasma levels of angiotensin II during different penile conditions in the
cavernous and systemic blood of healthy men and patients with erectile
dysfunction. Urology. 2001 Nov;58(5):805-10.
· Becker AJ, Uckert S, Stief CG, Truss MC, Machtens S, Scheller F, Knapp WH,
Hartmann U, Jonas U. Possible role of bradykinin and angiotensin II in the
regulation of penile erection and detumescence. Urology. 2001 Jan;57(1):193-8.
· De Angelis L, Marfella MA, Siniscalchi M, Marino L, Nappo F, Giugliano F, De
Lucia D, Giugliano D. Erectile and endothelial dysfunction in Type II diabetes:
a possible link. Diabetologia. 2001 Sep;44(9):1155-60.
· Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C,
Welch CB, Lusis AJ, Erickson SK, Farese RV Jr. Identification of a gene encoding
an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol
synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13018-23.
· Chapman VJ, Chapman DJ. (1980). Seaweeds and their uses. London: Chapman &
Hall.
· “Compound For Improving Neuralgia Containing Dibenzo-P-Dioxine Derivatives
Extracted From Marine Plants And Articles Comprising Thereof”. Korean Patent
Application 10-2004-0028066 (Livechem, Inc).
· Djukanovic, R., J.W. Wilson, K.M. Britten, S.J. Wilson, A.F. Walls, W.R.
Roche, P.H. Howarth, S.T. Holgate. 1990. Quantitation Of Mast Cells And
Eosinophils In The Bronchial Mucosal Of Symptomatic Atopic Asthmatics And
Healthy Control Subjects Using Immunohistochemistry. Am.Rev.Respir.Dis.
142:863-871.
· Fukuyama Y, Kodama M, Miura I, Kinzyo Z, Mori H, Nakayama Y, Takahashi M.
Anti-plasmin inhibitor. VI. Structure of phlorofucofuroeckol A, a novel
phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, from
Ecklonia kurome Okamura. Chem Pharm Bull (Tokyo). 1990 Jan;38(1):133-5.
· Fukuyama, Y., Kodama, M., Miura, I., Kinzyo, Z., Kido, M., Mori, H., Nakayama,
Y., Takahashi, M. Structure Of An Anti-Plasmin Inhibitor, Eckol, Isolated From
The Brown Alga Ecklonia Kurome Okamura And Inhibitory Activities Of Its
Derivatives On Plasmin Inhibitors. Chem. Pharm. Bull. 37: 349-353 (1989)
· Glombitza, K.W., Gerstberger, G. Phlorotannins With Dibenzodioxin Structural
Elements From The Brown Alga Eisenia Arborea. Phytochemistry 24: 543-551 (1985)
· Dorrance AM, Lewis RW, Mills TM. “Captopril Treatment Reverses Erectile
Dysfunction In Male Stroke Prone Spontaneously Hypertensive Rats.” Int J Impot
Res. 2002 Dec;14(6):494-7
· Hamed EA, Meki AR, Gaafar AA, Hamed SA. Role Of Some Vasoactive Mediators In
Patients With Erectile Dysfunction: Their Relationship With Angiotensin-Converting
Enzyme And Growth Hormone. Int J Impot Res. 2003 Dec;15(6):418-25.
· Henderson, W.R., Jr., D.B. Lewis, R.K. Albert, Y. Zhang, W.J.E. Lamm, G.K.S.
Chiang, F. Jones, P. Eriksen, Y. Tien, M. Jonas, E.Y. Chi. 1996. The Importance
Of Leukotrienes In Airway Inflammation In A Mouse Model Of Asthma. J. Exp. Med.
184:1483-1494.
· Henderson, W.R., Jr., E.Y. Chi, C.R. Maliszewski. 2000. Soluble Interleukin-4
Receptor (Sil-4R) Inhibits Airway Inflammation Following Allergen Challenge In A
Mouse Model Of Asthma. J. Immunol. 164:1086-1095.
· Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard
D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13
independently of IL-4 in experimental asthma. Science. 1998 Dec
18;282(5397):2261-3.
· Henderson, W.R., E.Y. Chi. 1985. Ultrastructural Characterization And
Morphometric Analysis Of Human Eosinophil Degranulation. J. Cell Sci. 73:33-48.
· Hoppe HA. (1979). Marine algae and their products and constituents in
pharmacy. In: Marine Algae in Pharmaceutical Science. Hoppe HA, Levring T,
Tanaka Y, eds. Berlin & New York: Walter de Gruyter.
· Hoshino, M., Y. Nakamura, J.J. Sim. 1998. Expression Of Growth Factors And
Remodeling Of The Airway Wall In Bronchial Asthma. Thorax 53:21-27.
· Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC. Antioxidative properties of
brown algae polyphenolics and their perspectives as chemopreventive agents
against vascular risk factors. Arch Pharm Res. 2003 Apr;26(4):286-93.
· Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Ham YM, Baik JS, Lee NH, Hyun JW.
Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage
via catalase activation. J Cell Biochem. 2006 Feb 15;97(3):609-20.
· Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park
JW, Ham YM, Lee NH, Hyun JW. Eckol isolated from Ecklonia cava attenuates
oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 2005
Nov 21;579(28):6295-304. Epub 2005 Oct 19.
· Kang, K., Park, Y., Hwang, H. J., Kim, S. H., Lee, J. G., Shin, H.-C. (2003).
Antioxidative Properties Of Brown Algae Polyphenolics And Their Perspectives As
Chemopreventive Agents Against Vascular Risk Factors. Arch. Pharm. Res.. 26:
286-293
· Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun
JW. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against
hydrogen peroxide induced cell damage. Free Radic Res. 2005 Aug;39(8):883-92.
· Kang, K.J., Hwang, H.J., Hong, D.H., Park, Y.J., Kim, S,H., Lee, B.H., Shin,
H.C. Anti-Oxidant And Anti-Inflammatory Activities Of Ventol, A Phlorotannin-Rich
Natural Agent Derived From Ecklonia Cava, And Its Effect On Proteoglycan
Degradation In Cartilage Explant Culture. Submitted To Molecular Pathology And
Pharmacology
· Kay, A.B. 1997. T Cells As Orchestrators Of The Asthmatic Response. Ciba
Found. Symp. 206:56-67.
· Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK.
Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase
activity. Life Sci. 2006 Sep 5;79(15):1436-43. Epub 2006 May 7.
· Krug, N., J. Madden, A.E. Redington, P. Lackie, R. Djukanovic, U. Schauer,
S.T. Holgate, A.J. Frew, P.H. Howarth. 1996. T-Cell Cytokine Profile Evaluated
At The Single Cell Level In Bal And Blood In Allergic Asthma. Am. J. Respir.
Cell Mol. Biol. 14:319-326.
· Lee, B.H., Stein, S. Improvement Of Learning Behavior Of Mice By An
Antiacetylcholinesterase And Neuroprotective Agent Nx42, A Laminariales-Alga
Extract. Presented To The Pharm. Soc. Kor., Spring Conference (2004); Manuscript
Submitted To Korean Journal Of Food Science And Technology.
· Lee, S.H., Han, S.B., Baik, J.Y. The Influence Of VNP Intake On The Symptoms
Of Osteoarthritis Of The Knee Joint. Clinical Report By Department Of Orthopedic
Surgery, Anam Hospital, Korea University Medical Center
· Kang KA, Zhang R, Lee KH, Chae S, Kim BJ, Kwak YS, Park JW, Lee NH, Hyun JW.
Protective effect of triphlorethol-A from Ecklonia cava against ionizing
radiation in vitro. J Radiat Res (Tokyo). 2006 Mar;47(1):61-8.
· Mcever, R.P. 1991. Selectins: Novel Receptors That Mediate Leukocyte Adhesion
During Inflammation. Thromb. Haemost. 65:223-228.
· Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS. Improvement of memory by
dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of
the inhibition of acetylcholinesterase. Arch Pharm Res. 2005 Jun;28(6):691-8.
· Nakamura, T., Nagayama, K., Uchida, K., Tanaka, R. Antioxidant Activity Of
Phlorotannins Isolated From The Brown Alga Eisenia Bicyclis. Fisheries Sci. 62:
923-926 (1996).
· Roche, W.R., R. Beasley, J.H. Williams, S.T. Holgate. 1989. Subepithelial
Fibrosis In The Bronchi Of Asthmatics. Lance 1:520-524.
· Ruehl ML, Orozco JA, Stoker MB, Mcdonagh PF, Coull BM, Ritter LS. Protective
Effects Of Inhibiting Both Blood And Vascular Selectins After Stroke And
Reperfusion. Neurol Res. 2002 Apr;24(3):226-32.
· Sheehan, D.C., B.B. Hrapchak. 1980. Connective Tissue/Muscle Fiber Stains. In
Theory And Practice Of Histotechnology. Battelle Press, Columbus, OH. 180-201.
· Shibata, T., Nagayama, K., Tanaka, R., Yamaguchi, K., Nakamura, T. Inhibitory
Effects Of Brown Algal Phlorotannins On Secretory Phospholipase A2S,
Lipoxygenases And Cycloxygenases. J. Appl. Phycol. 15: 61-66 (2003)
· Shin HC, Hwang HJ, Kang KJ, Lee BH. An antioxidative and antiinflammatory
agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm
Res. 2006 Feb;29(2):165-71.
· Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J,
Eckel RH, Farese RV Jr. Obesity resistance and multiple mechanisms of
triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May;25(1):87-90.
· Shibata, T., Fujimoto, K., Nagayama, K., Yamaguchi, K., Nakamura, T.
Inhibitory Activity Of Brown Algal Phlorotannins Against Hyaluronidase. Int. J.
Food Sci. Tech. 37: 703-709 (2002)
· Tsukada H, Nishiyama S, Fukumoto D, Ohba H, Sato K, Kakiuchi T. Effects of
acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal
system and cognitive function: Functional imaging of the conscious monkey brain
using animal PET in combination with microdialysis. Synapse. 2004
Apr;52(1):1-10.
· Virag R, Floresco J, Richard C. Impairment Of Shear-Stress-Mediated
Vasodilation Of Cavernous Arteries In Erectile Dysfunction. Int J Impot Res.
2004 Jan;16(1):39-42
· Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, C.L. Karp, D.D.
Donaldson. 1998. Interleukin-13: Central Mediator Of Allergic Asthma. Science
282:2258-2261.
· Temann UA, Prasad B, Gallup MW, Basbaum C, Ho SB, Flavell RA, Rankin JA. A
novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and
mucin hypersecretion. Am J Respir Cell Mol Biol. 1997 Apr;16(4):471-8.
· Zhu, Z., R.J. Homer, Z. Wang, Q. Chen, G.P. Geba, J. Wang, Y. Zhang, J.A.
Elias. 1999. Pulmonary Expression Of Interleukin-13 Causes Inflammation, Mucus
Hypersecretion, Subepithelial Fibrosis, Physiologic Abnormalities, And Eotaxin
Production. J. Clin. Invest. 103:779-78
· Uhm CS, Kim KB, Lim JH, Pee DH, Kim YH, Kim H, Eun BL, Tockgo YC. Effective
treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats.
Neurosci Lett. 2003 Dec 15;353(1):21-4
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